Joplings Handbook of Leprosy 7th EdItion | Diagnosis, Management & Prevention

Joplings Handbook of Leprosy, 7th Edition continues to be one of the most trusted and concise resources for understanding leprosy, now widely referred to as Hansen’s disease. This edition provides updated clinical guidance for dermatologists, infectious disease specialists, general physicians, and trainees working in endemic and non-endemic regions. The handbook distills decades of experience into an accessible format that supports accurate diagnosis, effective treatment, and long-term patient management.

The book begins with an overview of Mycobacterium leprae biology, transmission pathways, and immunological principles, helping clinicians understand disease progression and host response. Detailed descriptions of the Ridley–Jopling classification and WHO operational categories provide a foundation for distinguishing the spectrum of disease from tuberculoid to lepromatous forms. Clinical photographs and illustrations support recognition of cardinal signs including anesthetic patches, nerve thickening, and typical skin lesions.

A major strength of the handbook lies in its diagnostic clarity, offering structured approaches to clinical evaluation, slit-skin smear techniques, biopsy considerations, and differential diagnosis. The text emphasizes early recognition to reduce disability and prevent transmission, particularly in resource-limited settings where laboratory support may be minimal. Algorithms support decision-making when patients present with sensory loss, neuropathic pain, or hypopigmented macules.

Up-to-date sections on multidrug therapy (MDT) describe standard WHO treatment regimens, individualized modifications, drug resistance concerns, and strategies to improve adherence. Expanded discussions focus on monitoring response, managing therapy interruptions, and addressing challenges in special populations, including children, pregnant individuals, and those with comorbidities.Joplings Handbook of Leprosy 7th EdItion

The handbook provides thorough coverage of leprosy reactions, including Type 1 (reversal reaction) and Type 2 (erythema nodosum leprosum), which remain major causes of nerve damage and disability. The text guides readers through recognition, grading of severity, and use of corticosteroids, thalidomide, clofazimine, and supportive interventions. Protocols for preventing recurrent reactions and mitigating nerve inflammation promote functional preservation.

Neuropathy management is a core focus, with descriptions of nerve involvement, sensory testing, tendon transfer procedures, ulcer care, and rehabilitation strategies. The book underscores the importance of early detection of nerve impairment through simple clinical tools and periodic assessments, enabling timely intervention to prevent permanent disability.

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