Androgenetic Alopecia From A to Z – Vol.1 Basic Science Comprehensive

Androgenetic Alopecia From A to Z: Vol.1 Basic Science is a comprehensive reference dedicated to understanding the underlying biology of androgenetic alopecia (AGA), the most common form of hair loss affecting both men and women. This volume focuses on the basic scientific foundations, providing clinicians, researchers, and trichology specialists with in-depth knowledge of disease mechanisms.

The book begins with hair follicle anatomy and physiology, describing normal hair growth cycles, follicular stem cells, and the molecular pathways regulating hair growth and shedding. It then examines the pathophysiology of androgenetic alopecia, detailing androgen metabolism, androgen receptor signaling, and the role of dihydrotestosterone (DHT) in follicular miniaturization.

A significant focus is given to genetics and molecular biology. The text explores hereditary patterns, candidate genes, epigenetic regulation, and signaling pathways involved in AGA. Understanding these mechanisms provides the foundation for developing targeted therapies and novel treatment strategies.

The volume also addresses cellular and molecular mechanisms, including Wnt/β-catenin signaling, apoptosis, inflammation, oxidative stress, and microinflammation in hair follicles. Readers gain a detailed understanding of the complex interplay between systemic and local factors contributing to androgenetic alopecia.

Key features of this book include:

• Comprehensive review of basic science mechanisms underlying AGA.

• Insights into genetic, hormonal, and molecular factors influencing hair loss.

• Detailed illustrations, diagrams, and molecular pathway charts for clarity.

• Emphasis on translating basic science knowledge into potential clinical applications and research directions.

Designed for dermatologists, trichologists, medical researchers, and postgraduate trainees, this volume provides the scientific foundation required to understand hair loss and evaluate emerging treatments. It serves as an essential resource for those involved in both clinical practice and laboratory research in hair disorders.

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